Development of a porous, titanium implant for the treatment of vertebral fractures

Vertebral fractures are the second most common fractures in a growing group of osteoporosis patients. Surgical intervention is essential to stabilize the vertebra and prevent immobility due to the fracture. Current treatment have major complications of which many of them are related to consumption of PMMA bone cement (e.g. leakage, adjacent feature, embolism and neurological deficits). The collaboration of Amber Implants and CAM Bioceramics is seeking for a robust and innovative solution. The aim of this project is to develop and pre-clinically test a porous titanium implant for the treatment of vertebral fractures. In this project a unique 3D printed implant is being developed, the AIM +, which can be made to measure and promote bone in-growth in an innovative way. The AIM + will be able to mimic the mechanical properties of bone. Thanks to the in-situ expansion of the implant, the height of the vertebra can be optimally reconstructed. In addition, the porous structure and choice of materials provides natural fixation and stimulates bone growth.

One of the most important distinguishing features of the implant is the limitation and later omission of the use of the bone cement PMMA which causes many complications. In order to establish a strong attachment between the implant and the surrounding bone, a coating and a new bone cement are developed from material that corresponds to that of natural bone, is bioabsorbable and stimulates natural bone ingrowth. This project creates new opportunities for the life science and health sector and increases the competitiveness of SMEs in South Holland.