Bactericidal Coating on Complex Titanium Implants (BCCTI)

Start day

01/07/2018

End date

30/06/2020

Overall Objectives

BCCTI will optimize the parameters of EPD technique in order to make a uniform and consistent antibacterial coating on geometrically complex and porous titanium implants.

Introduction

Implant-associated infections (IAI) are notoriously difficult to treat because bacteria on an implant can create an impermeable layer of tissue, a so-called biofilm. This biofilm is relatively insensitive for most antibiotics and once established, often a re-operation is required in which the implant plus all biofilm tissue has to be removed. Infection rates range between 1 and 40%, dependent on operation type, status of the patient and location. In particular, revision and trauma operations have a high infection risk. Orthopaedic infections have significant costs and a high morbidity for the patient.

The current project aims to develop a prophylactic bactericidal coating via electrophoretic deposition (EPD) technology in combination with a 3D printed porous titanium implant that has a huge surface area to reduce the infection rate. The project will provide an excellent opportunity to continue this development in a clinical trial and subsequently bring this unique infection prophylactic coating to the market.

Expected results

Reduce the time and cost of hospitalization as well as surgery and rehabilitation. These will be achieved by minimizing the time and related costs spent for:

  • Implant fabrication
  • The surgery duration
  • Post-surgical activities